Ultra Pure NMN - 500mg

Once ingested, NMN is absorbed into the bloodstream and transported into cells through a protein called SLC12A8.

Inside the cell, it is converted into NAD⁺ a coenzyme involved in many biological processes.

This transport mechanism was described in a 2019 study published in Nature Metabolism by Dr. Shin-ichiro Imai’s team, which suggested that NMN can be taken up directly by cells without first converting to NR which was the accepted notion prior.

Research continues into how NMN uptake varies across different tissues, particularly in those with high NAD⁺ turnover, such as the brain, muscles, and liver.

NMN doesn’t typically produce fast or obvious effects and experiences can vary from person to person.

Some studies have explored changes in NAD⁺ levels after consistent use for 8 to 12 weeks, and these findings vary depending on dosage and individual factors. Some of which we have linked on theScience Page.Some users choose to track their progress usingintracellular NAD⁺ tests, taken before and after supplementation.

his can provide a more objective way to understand how NAD⁺ levels may respond over time.

Like with nutrients such as vitamin D, you may not always “feel” a difference - but that doesn’t mean important processes aren’t happening in the background.

The NAD+ molecule is too large to pass through cell membranes efficiently. NMN, being smaller and transported directly into cells, is a more effective precursor.

Analogy:

Imagine NAD+ as a fully assembled sofa—it won’t fit through the door. NMN acts as the smaller pieces, easily carried into the house and reassembled into NAD+ where it’s needed.

The recommended dose for Element 5 NMN is 500 mg per day (one capsule), taken in the morning with water.

Study Evidence:

A study published in Frontiers in Nutrition demonstrated that 250 mg of NMN nearly doubled NAD+ levels in humans over 12 weeks. NAD+ levels returned to baseline within 4 weeks after stopping supplementation.

other study observed significant NAD+ increases with daily doses of 300 mg, 600 mg, and 900 mg. Improvements in muscle endurance (measured by a 6-minute walking test) with those at higher dosages walking further. As well as perceived health was greater at higher doses at 30 days compared to 300mg dosage. 

This evidence suggests consistent NMN use at 600 mg/day for 30–60 days may yield measurable benefits.

NAD+ (Nicotinamide Adenine Dinucleotide) is a naturally occurring coenzyme found in every living cell.

It plays a key role in cellular processes such as energy metabolism and is involved in important biological pathways like sirtuin activation.

Scientists continue to study NAD+ for its role in maintaining healthy cellular function, especially as levels are known to decline with age.

NR (Nicotinamide Riboside) is another NAD+ precursor that is converted into NMN in the body before eventually forming NAD+.

NMN enters the NAD⁺ biosynthesis pathway at a later stage, meaning it may bypass one conversion step.