Element 5™ NMN - Nicotinamide Mononucleotide

It’s completely up to you - choose a time that fits your routine.

Many customers prefer to take NMN in the morning, but it can be taken at any time of day.

NMN can be taken with or without food; a glass of water is all you need.

Once ingested, NMN is absorbed into the bloodstream and transported into cells through a protein called SLC12A8.

Inside the cell, it is converted into NAD⁺ a coenzyme involved in many biological processes.

This transport mechanism was described in a 2019 study published in Nature Metabolism by Dr. Shin-ichiro Imai’s team, which suggested that NMN can be taken up directly by cells without first converting to NR which was the accepted notion prior.

Research continues into how NMN uptake varies across different tissues, particularly in those with high NAD⁺ turnover, such as the brain, muscles, and liver.

NMN doesn’t typically produce fast or obvious effects and experiences can vary from person to person.

Some studies have explored changes in NAD⁺ levels after consistent use for 8 to 12 weeks, and these findings vary depending on dosage and individual factors. Some of which we have linked on the Science Page.

Some users choose to track their progress using intracellular NAD⁺ tests, taken before and after supplementation.

his can provide a more objective way to understand how NAD⁺ levels may respond over time.

Like with nutrients such as vitamin D, you may not always “feel” a difference - but that doesn’t mean important processes aren’t happening in the background.

The NAD+ molecule is too large to pass through cell membranes efficiently. NMN, being smaller and transported directly into cells, is a more effective precursor.

Analogy:

Imagine NAD+ as a fully assembled sofa—it won’t fit through the door. NMN acts as the smaller pieces, easily carried into the house and reassembled into NAD+ where it’s needed.

The recommended dose for Element 5 NMN is 500 mg per day (one capsule), taken in the morning with water.

Study Evidence:

A study published in Frontiers in Nutrition demonstrated that 250 mg of NMN nearly doubled NAD+ levels in humans over 12 weeks. NAD+ levels returned to baseline within 4 weeks after stopping supplementation.

Another study observed significant NAD+ increases with daily doses of 300 mg, 600 mg, and 900 mg. Improvements in muscle endurance (measured by a 6-minute walking test) with those at higher dosages walking further. As well as perceived health was greater at higher doses at 30 days compared to 300mg dosage. 

This evidence suggests consistent NMN use at 600 mg/day for 30–60 days may yield measurable benefits.

NAD+ (Nicotinamide Adenine Dinucleotide) is a naturally occurring coenzyme found in every living cell.

It plays a key role in cellular processes such as energy metabolism and is involved in important biological pathways like sirtuin activation.

Scientists continue to study NAD+ for its role in maintaining healthy cellular function, especially as levels are known to decline with age.

NR (Nicotinamide Riboside) is another NAD+ precursor that is converted into NMN in the body before eventually forming NAD+.

NMN enters the NAD⁺ biosynthesis pathway at a later stage, meaning it may bypass one conversion step.

NAD+ is a coenzyme found in all living cells. It plays a central role in cellular energy metabolism and is involved in processes related to cellular maintenance and stress response.

Research is ongoing into how NAD+ interacts with proteins like sirtuins, which are being studied for their role in healthy aging and cell regulation. Scientists are particularly interested in how NAD+ levels change over time and their potential relationship with cellular health.

NMN is found in small amounts in foods like edamame, broccoli, cabbage, avocados, and cucumbers. However, the natural content is quite low.
For example, edamame contains about 1.8mg of NMN per 100g - so to reach a 500mg daily dose, you’d need to eat roughly:

• 26.5kg of edamame
• 40kg of cucumber
• 80kg of avocado
• 55kg of cabbage
  

That’s why many people interested in NMN choose to take it in concentrated supplement form.

Yes! Here’s what you can expect:

• Open the capsule and pour the contents into water.
• NMN may initially sink to the bottom in small clumps, this is completely normal.
• Stir the water, and it will turn cloudy as the NMN begins to dissolve.

Notes:

• If left to settle, the water will gradually clear from the bottom up.
• A thin white foam on the surface is just NMN that hasn’t fully dissolved, simply stir again.
• NMN doesn’t need to fully dissolved to be effective; it’s purely a matter of personal preference.

This is one of the most common questions we get - and we understand why. A lot of online marketing promises fast results, but NMN doesn’t work like that.

NMN is a precursor to NAD+, a molecule naturally found in your body that’s involved in cellular energy and maintenance. The purpose of taking NMN is to support NAD+ levels over time, not to create instant, noticeable effects.

Everyone responds differently. Some people feel a difference quickly, others don’t feel anything at all - but that doesn’t mean it’s not working at a cellular level.

That’s why we don’t recommend measuring progress by how you “feel” after a few days or weeks. Instead, we suggest a more objective approach:

• Take an NAD+ test before you start
• Re-test after 60–90 days (or longer for best insight)
  

Remember: the goal is to maintain higher NAD+ levels over time - so your body has what it needs to support cellular health in the long run.